PF 573228

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

PF-573228 是一种 ATP 竞争性 FAK 抑制剂，在无细胞测定中 IC50 为 4 nM，对 FAK 的选择性是 Pyk2、CDK1/7 和 GSK-3β 的约 50 至 250 倍。

PF-573228 is an ATP-competitive inhibitor of FAK with IC50 of 4 nM in a cell-free assay, ~50- to 250-fold selective for FAK than Pyk2, CDK1/7 and GSK-3β.(In Vitro):PF-573228 inhibits purified recombinant catalytic fragment of FAK with an IC50 of 4 nM. In cultured cells, PF-573228 inhibits FAK phosphorylation on Tyr397 with an IC50 of 30-100 nM. Treatment of cells with concentrations of PF-573228 that significantly decreased FAK Tyr397 phosphorylation fails to inhibit cell growth or induce apoptosis. In contrast, treatment with PF-573228 inhibits both chemotactic and haptotactic migration concomitant with the inhibition of focal adhesion turnover.

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FAK Inhibitor II | Focal Adhesion Kinase Inhibitor II

Tyrosine Kinase

FAK

FAK

Cancer

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869288-64-2

491.49

C22H20F3N5O3S

>98% (HPLC)

DMSO: 26 mg/mL (52.9 mM)

O=C1NC2=C(C=C(NC3=NC=C(C(F)(F)F)C(NCC4=CC=CC(S(=O)(C)=O)=C4)=N3)C=C2)CC1

3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone

(-20℃)

With Ice Pack

≥ 2 years